TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration
نویسندگان
چکیده
SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.
منابع مشابه
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عنوان ژورنال:
- Neuron
دوره 93 شماره
صفحات -
تاریخ انتشار 2017